Kevan M. Shokat

Kevan M. Shokat, Professor of University of California San Francisco, San Francisco, U.S.A. Research in his laboratory is focused on the discovery of new chemical based tools to decipher cellular signaling networks with an emphasis on protein kinases and more recently, GTPases. The analysis of signal transduction pathways has proven challenging using the traditional tools of biochemistry, genetics, and chemistry. Biochemical approaches are often limited in utility because signaling networks span from the cell surface to the control of transcription and translation, confounding reconstitution efforts from purified proteins. Genetic approaches allow specific perturbation of single components in an intact cell or organism, yet are often confounded by the emergent properties of signaling cascades. Chemical and pharmacological approaches enable rapid, reversible, and graded (dose-dependent) inactivation of single components in intact cells or organisms. Unfortunately, highly selective chemical probes (agonists, antagonists, traceable substrates, etc.) of protein kinases are difficult to develop because the 500 protein kinases share highly homologous ATP binding pockets. My laboratory has solved this fundamental problem for the largest family of enzymes in the human genome, protein kinases, by development of a strategy based on a combination of protein engineering and organic synthesis. We have termed this approach chemical genetics. 活动家作为专业第三方嘉宾邀约平台，依托互联网公开数据为您提供嘉宾信息展示服务。若您发现嘉宾信息需要更新或移除，请发送邮件或联系客服。 我们专注于根据您的具体需求（包括演讲议题、会议日期及活动预算等），为您精准匹配各领域专业嘉宾。 为高效服务，建议您提前准备好详细活动信息，并拨打客服电话：18911802888（工作日9:00-18:00）。 温馨提示：本服务仅限嘉宾邀约相关事宜，其他需求暂不处理，感谢您的理解与配合。